Intestinal genetic inactivation of caspase-8 diminishes migration of enterocytes
Elke Kaemmerer, Paula Kuhn, Ursula Schneider, Min Kyung Jeon, Christina Klaus, Miriam Schiffer, Danika Weisner, Jörg Jäkel, Nikolaus Gassler, Institute of Pathology, RWTH Aachen University, 52074 Aachen, Germany
Elke Kaemmerer, Norbert Wagner, Department of Pediatrics, RWTH Aachen University, 52074 Aachen, Germany
Christian Liedtke, Department of Medicine III, RWTH Aachen University, 52074 Aachen, Germany
Lieven Nils Kennes, Ralf-Dieter Hilgers, Department of Medical Statistics, RWTH Aachen University, 52074 Aachen, Germany
Author contributions: Kaemmerer E and Kuhn P contributed equally; Kaemmerer E, Klaus C and Gassler N designed the research; Kaemmerer E, Kuhn P, Schneider U and Jeon MK performed the research; Schiffer M, Liedtke C, Jäkel J, Weisner D, Kennes LN and Hilgers RD contributed analytic tools; Kaemmerer E, Liedtke C, Hilgers RD, Wagner N and Gassler N wrote the paper.
Supported by Deutsche Forschungsgemeinschaft, No. DFG GA 785/5-1 (partially); and Deutsche Krebshilfe, No. GA 109313 (partially).
Ethics approval: The study was reviewed and approved by the Authority for Environment Conservation and Consumer Protection of the State North Rhine-Westfalia Institutional Review Board.
Institutional animal care and use committee: All procedures were approved by the Authority for Environment Conservation and Consumer Protection of the State North Rhine-Westfalia (IACUC protocol number: LANUV, Germany; 84-02.04.2013.A034).
Conflict-of-interest: The authors report no conflicts of interest.
Data sharing: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Nikolaus Gassler, MA, Professor, Institute of Pathology, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany. firstname.lastname@example.org
Telephone: +49-241-8088897 Fax: +49-241-8082439
Received: October 15, 2014
Peer-review started: October 18, 2014
First decision: November 14, 2014
Revised: December 2, 2014
Accepted: January 30, 2015
Article in press: January 30, 2015
Published online: April 21, 2015