Clinical Trials Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 7, 2015; 21(13): 3983-3993
Published online Apr 7, 2015. doi: 10.3748/wjg.v21.i13.3983
Decreased STAT4 indicates poor prognosis and enhanced cell proliferation in hepatocellular carcinoma
Gang Wang, Jia-Hui Chen, Yong Qiang, Dong-Zhi Wang, Zhong Chen
Gang Wang, Yong Qiang, Dong-Zhi Wang, Zhong Chen, Department of General Surgery, Medical School of Nantong University, Nantong 226000, Jiangsu Province, China
Jia-Hui Chen, Department of Cardiology, Medical School of Fudan University, Shanghai 200000, China
Author contributions: Wang G designed the study; Wang G and Chen JH performed the study; Wang DZ and Qiang Y contributed reagents or analysis tools; and Wang G analyzed the data and wrote the manuscript; all the authors contributed to this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Zhong Chen, Professor, Department of General Surgery, Medical School of Nantong University, West Temple Road, Nantong 226000, Jiangsu Province, China.
Telephone: +86-513-81161001
Received: September 22, 2014
Peer-review started: September 23, 2014
First decision: October 14, 2014
Revised: November 1, 2014
Accepted: December 5, 2014
Article in press: December 8, 2014
Published online: April 7, 2015
Core Tip

Core tip: In this study, we assessed the role of signal transduction and activation of transcription 4 in hepatocellular carcinoma (HCC) and discussed the possible function of this protein in the development of HCC.