Published online Mar 28, 2015. doi: 10.3748/wjg.v21.i12.3607
Peer-review started: September 18, 2014
First decision: October 29, 2014
Revised: December 3, 2014
Accepted: January 21, 2015
Article in press: January 21, 2015
Published online: March 28, 2015
Core tip: The diagnosis of gastric infiltrating tumors is challenging, which is often delayed due to negative endoscopic and histological tests. We for the first time investigated the deep and large biopsy technique for diagnosis of gastric infiltrating tumors with negative malignant endoscopy biopsies. This biopsy technique combined bite-on-bite technique with or without endoscopic mucosal resection. Endoscopic ultrasound was used to select the thickest site for biopsy. The biopsy provided a definitive and conclusive diagnosis in 29 (80.6%) of the 36 patients. Neither severe hemorrhage nor perforation occurred. It is an effective and safe diagnostic method for gastric infiltrating tumors with negative endoscopy biopsies.