Thiopurine metabolites variations during co-treatment with aminosalicylates for inflammatory bowel disease: Effect of N-acetyl transferase polymorphisms
Gabriele Stocco, Giuliana Decorti, Department of Life Sciences, University of Trieste, I-34127 Trieste, Italy
Eva Cuzzoni, PhD School in Sciences of Reproduction and Development, University of Trieste, I-34127 Trieste, Italy
Alessandro Ventura, Department of Medical, Surgical and Health Sciences, University of Trieste, I-34127 Trieste, Italy
Sara De Iudicibus, Diego Favretto, Stefano Martelossi, Alessandro Ventura, Institute for Maternal and Child Health IRCCS Burlo Garofolo, I-34127 Trieste, Italy
Noelia Malusà, Department of Prevention, Sanitary Services Agency Number 1, I-34127 Trieste, Italy
Elena Pozzi, Paolo Lionetti, Research Children’s Hospital “Meyer”, I-50139 Florence, Italy
Author contributions: Stocco G, Martelossi M, Ventura A and Decorti G designed the study; Martelossi S, Lionetti P, Pozzi E and Ventura A enrolled the patients; Cuzzoni E, De Iudicibus S, Favretto D and Malusà N genotyped samples and performed the high performance liquid chromatography analyses; Stocco G, Cuzzoni E, De Iudicibus S and Decorti G wrote the paper; all authors critically discussed the results.
Supported by Italian Ministry of Health, and Fondazione Benefica Alberto e Kathleen Casali.
Ethics approval: The study was reviewed and approved by the Institute for Maternal and Child Health I.R.C.C.S. Burlo Garofolo Medical Etics Review Board, approval Trieste (n. 58/05, 12/12/2005) and by the Institutional Research Board (#23/05).
Informed consent: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest: All authors declare they have no conflict of interest.
Data sharing: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Giuliana Decorti, MD, Professor, Department of Life Sciences, University of Trieste, via Fleming 22, I-34127 Trieste, Italy. email@example.com
Telephone: +39-40-5588777 Fax: +39-40-5582134
Received: October 1, 2014
Peer-review started: October 3, 2014
First decision: October 29, 2014
Revised: November 23, 2014
Accepted: January 16, 2015
Article in press: January 16, 2015
Published online: March 28, 2015