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World J Gastroenterol. Mar 28, 2015; 21(12): 3492-3498
Published online Mar 28, 2015. doi: 10.3748/wjg.v21.i12.3492
Long-chain acyl-CoA synthetase in fatty acid metabolism involved in liver and other diseases: An update
Sheng Yan, Xue-Feng Yang, Hao-Lei Liu, Nian Fu, Yan Ouyang, Kai Qing
Sheng Yan, Xue-Feng Yang, Hao-Lei Liu, Nian Fu, Department of Gastroenterology, Affiliated Nanhua Hospital of University of South China, Hengyang 421001, Hunan Province, China
Yan Ouyang, Department of Nephrology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
Kai Qing, Department of Hematology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
Author contributions: Yang XF designed the paper; Yan S performed research of literature data and wrote the paper; Liu HL wrote the paper; Fu N performed research of literature data and revised the paper; Ouyang Y and Qing K revised the paper.
Supported by National Natural Science Foundation of China, No. 81373465.
Conflict-of-interest: We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work. There is no professional or other personal interest of any nature or kind in any product, service and/or company that could be construed as influencing the position presented in, or the review of, the manuscript entitled.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Xue-Feng Yang, Professor, Department of Gastroenterology, Affiliated Nanhua Hospital of University of South China, No. 336, South Dongfeng Road, Hengyang 421001, Hunan Province, China. yxf9988@126.com
Telephone: +86-734-8358399 Fax: +86-734-8358399
Received: September 30, 2014
Peer-review started: September 30, 2014
First decision: October 29, 2014
Revised: November 18, 2014
Accepted: January 21, 2015
Article in press: January 21, 2015
Published online: March 28, 2015
Processing time: 181 Days and 12.6 Hours
Core Tip

Core tip: Recent research has shown that long-chain acyl-CoA synthetase (ACSL) family members have individual functions in fatty acid metabolism in different types of cells depending on substrate preferences, subcellular location and tissue specificity, thus contributing to several diseases. These enzymes also regulate cell proliferation and apoptosis through different mechanisms. This review addresses new findings in the fatty acid metabolism-associated effects of ACSLs in diseases.