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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 21, 2015; 21(11): 3239-3244
Published online Mar 21, 2015. doi: 10.3748/wjg.v21.i11.3239
Published online Mar 21, 2015. doi: 10.3748/wjg.v21.i11.3239
Effects of urotensin-II on cytokines in early acute liver failure in mice
Liang-Ming Liu, Liang Zhao, Dong-Yu Liang, Fang-Ping Yu, Chang-Gen Ye, Wen-Juan Tu, Tong Zhu, Department of Hepatology, Songjiang Hospital Affiliated to the First People’s Hospital, Shanghai Jiaotong University, Shanghai 201600, China
Author contributions: Liu LM designed research; Zhao L, Liang DY, Yu FP, Ye CG, Tu WJ and Zhu T performed research; Liu LM contributed new reagents/analytic tools; Liu LM and Zhao L analyzed data; and Liu LM and Zhao L wrote the paper.
Supported by National Natural Science Foundation of China, No. 81070357 and No. 30660066.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Liang-Ming Liu, MD, PhD, Department of Hepatology, Songjiang Hospital Affiliated to the First People’s Hospital, Shanghai Jiaotong University, No. 746 Mid-Zhongshan Road, Songjiang District, Shanghai 201600, China. liuliangming@hotmail.com
Telephone: +86-21-67720053 Fax: +86-21-67720053
Received: July 7, 2014
Peer-review started: July 8, 2014
First decision: September 15, 2014
Revised: October 23, 2014
Accepted: December 16, 2014
Article in press: December 16, 2014
Published online: March 21, 2015
Peer-review started: July 8, 2014
First decision: September 15, 2014
Revised: October 23, 2014
Accepted: December 16, 2014
Article in press: December 16, 2014
Published online: March 21, 2015
Core Tip
Core tip: In this study, we found that urotensin-II (UII) increased before tumor necrosis factor (TNF)-α and interleukin (IL)-1β following lipopolysaccharide/D-galactosamine challenge. Furthermore, pretreatment with urantide, an inhibitor of the UII receptor, blocked TNF-α and IL-1β increases following downregulation of UII in liver and blood at different time points after challenge. Therefore, UII may play a pivotal role in the pathogenesis and priming of acute liver failure by triggering the inflammatory cascade, and initiating and driving the early release of TNF-α and IL-1β in lipopolysaccharide/D-galactosamine-challenged mice.