Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 21, 2015; 21(11): 3157-3165
Published online Mar 21, 2015. doi: 10.3748/wjg.v21.i11.3157
Update on the management of pancreatic cancer: Surgery is not enough
Daniel Ansari, Adam Gustafsson, Roland Andersson
Daniel Ansari, Adam Gustafsson, Roland Andersson, Department of Surgery, Clinical Sciences Lund, Lund University and Skåne University Hospital, SE-221 85 Lund, Sweden
Author contributions: Ansari D and Gustafsson A performed the literature search; Andersson R designed the study and revised the manuscript; all authors were involved in manuscript writing and read and approved the final manuscript.
Conflict-of-interest: The authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Roland Andersson, MD, PhD, Department of Surgery, Clinical Sciences Lund, Lund University and Skåne University Hospital, Getingevägen 4, SE-221 85 Lund, Sweden. roland.andersson@med.lu.se
Telephone: +46-46-172359
Received: November 12, 2014
Peer-review started: November 15, 2014
First decision: December 11, 2014
Revised: December 19, 2014
Accepted: February 5, 2015
Article in press: February 5, 2015
Published online: March 21, 2015
Core Tip

Core tip: This review updates the current progress in the management of pancreatic cancer with focus on novel modes of diagnosis and treatment. New blood-based biomarkers for early detection based on genetic, epigenetic and protein changes in pancreatic cancer are discussed and new treatment strategies such as stromal depletion are highlighted. Pancreatic cancer is a systemic disease already at diagnosis and demands multimodal managements strategies in order to improve outcomes.