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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 14, 2015; 21(10): 2937-2948
Published online Mar 14, 2015. doi: 10.3748/wjg.v21.i10.2937
Published online Mar 14, 2015. doi: 10.3748/wjg.v21.i10.2937
Heme oxygenase-1 protects rat liver against warm ischemia/reperfusion injury via TLR2/TLR4-triggered signaling pathways
Han-Fei Huang, Zhong Zeng, Kun-Hua Wang, Hai-Yan Zhang, Shuai Wang, Wen-Xiang Zhou, Zhan-Bo Wang, Wang-Gang Xu, Jian Duan, Organ Transplantation Center, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China
Author contributions: Huang HF and Zeng Z contributed equally to this work; Huang HF, Zhang HY and Wang S performed the majority of experiments; Zhou WX and Wang ZB performed data analysis; Xu WG and Duan J were involved in editing the manuscript; Wang KH designed the study.
Supported by National Natural Science Foundation of China, No. 81360079; and Yunnan Provincial Science and Technology Department and Kunming Medical University Collaborative Fund, No. 2013FB142.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Zhong Zeng, MD, Organ Transplantation Center, the First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming 650032, Yunnan Province, China. zzong@medmail.com.cn
Telephone: +86-871-65324888 Fax: +86-871-65359202
Received: July 3, 2014
Peer-review started: July 4, 2014
First decision: July 21, 2014
Revised: August 9, 2014
Accepted: November 7, 2014
Article in press: November 11, 2014
Published online: March 14, 2015
Peer-review started: July 4, 2014
First decision: July 21, 2014
Revised: August 9, 2014
Accepted: November 7, 2014
Article in press: November 11, 2014
Published online: March 14, 2015
Core Tip
Core tip: Heme oxygenase (HO)-1, a rate-limiting enzyme in heme degradation, has been shown to provide cytoprotection in various tissue and organ injury models. There is evidence suggesting that augmented Toll-like receptor (TLR) reactivity contributes to the development of heightened systemic inflammation following severe liver injury. In this study, by inducing the expression of HO-1 in a rat liver ischemia/reperfusion injury model, we demonstrated that HO-1 suppresses activation of the TLR2/TLR4-triggered myeloid differentiation factor 88 dependent pathway and promotes expression of negative regulators of TLR signaling.