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Burock S, Herrmann P, Wendler I, Niederstrasser M, Wernecke KD, Stein U. Circulating metastasis associated in colon cancer 1 transcripts in gastric cancer patient plasma as diagnostic and prognostic biomarker. World J Gastroenterol 2015; 21(1): 333-341 [PMID: 25574109 DOI: 10.3748/wjg.v21.i1.333]
World J Gastroenterol. Jan 7, 2015; 21(1): 333-341 Published online Jan 7, 2015. doi: 10.3748/wjg.v21.i1.333
Circulating metastasis associated in colon cancer 1 transcripts in gastric cancer patient plasma as diagnostic and prognostic biomarker
Susen Burock, Pia Herrmann, Ina Wendler, Markus Niederstrasser, Klaus-Dieter Wernecke, Ulrike Stein
Susen Burock, Charité Comprehensive Cancer Center, Invalidenstraße 80, 10117 Berlin, Germany
Pia Herrmann, Ulrike Stein, Experimental and Clinical Research Center, Charité University Medicine Berlin and Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Straße 10, 13125 Berlin, Germany
Ina Wendler, Markus Niederstrasser, Charité University Medicine Berlin, Lindenberger Weg 80, 13125 Berlin, Germany
Klaus-Dieter Wernecke, Institute of Medical Biometry, Charité University Medicine Berlin, Luisenstraße 65, 10117 Berlin, Germany
Author contributions: Burock S and Stein U designed the concept of the study; Herrmann P performed qRT-PCR; Burock S, Herrmann P, Wendler I and Stein U analyzed the data; Burock S, Niederstrasser M and Wernecke KD performed statistical analyses; Burock S and Stein U wrote the manuscript.
Correspondence to: Ulrike Stein, Professor, Experimental and Clinical Research Center, Charité University Medicine Berlin and Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Straße 10, 13125 Berlin, Germany. ustein@mdc-berlin.de
Telephone: +49-30-94063432 Fax: +49-30-94062780
Received: March 21, 2014 Peer-review started: March 23, 2014 First decision: April 2, 2014 Revised: May 5, 2014 Accepted: July 22, 2014 Article in press: July 22, 2014 Published online: January 7, 2015 Processing time: 291 Days and 17.6 Hours
Core Tip
Core tip: We provide for the first time a blood-based assay for transcript quantification of the metastasis inducer Metastasis Associated in Colon Cancer 1 (MACC1) in a prospective study of gastric cancer patients. MACC1 is a strong prognostic biomarker for tumor progression and metastasis in a variety of solid cancers. We discriminated tumor-free volunteers and gastric cancer patients (all P < 0.001, sensitivity 0.68 (95%CI: 0.45-0.85), specificity 0.89 (95%CI: 0.77-0.95) of each disease stage (P < 0.05 for each). Shorter survival correlated with high circulating MACC1 transcript levels (P = 0.0015). Thus, circulating MACC1 transcript levels in plasma of gastric cancer patients are of diagnostic value and are prognostic for patient survival.
