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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 7, 2015; 21(1): 240-245
Published online Jan 7, 2015. doi: 10.3748/wjg.v21.i1.240
Published online Jan 7, 2015. doi: 10.3748/wjg.v21.i1.240
Helicobacter pylori infection in patients with selective immunoglobulin E deficiency
Eli Magen, Menachem Schlesinger, Itzhak Ben-Zion, Daniel Vardy, Leumit Health Services, Ashdod 77456, Israel
Eli Magen, Allergy and Clinical Immunology Unit, Barzilai University Medical Center, Ashkelon 78278, Israel
Daniel Vardy, Ben-Gurion University of Negev, Beer-Sheva 8410501, Israel
Author contributions: Magen E designed the research and wrote the paper; Magen E and Vardy D performed the research; Magen E, Schlesinger M and Ben-Zion I analyzed the data.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Eli Magen, MD, Allergy and Clinical Immunology Unit, Barzilai University Medical Center, 2 Hahistadrout St, Ashkelon 78278, Israel. allergologycom@gmail.com
Telephone: +972-8-6745710 Fax: +972-8-6745712
Received: April 20, 2014
Peer-review started: April 20, 2014
First decision: May 13, 2014
Revised: June 10, 2014
Accepted: July 11, 2014
Article in press: July 11, 2014
Published online: January 7, 2015
Peer-review started: April 20, 2014
First decision: May 13, 2014
Revised: June 10, 2014
Accepted: July 11, 2014
Article in press: July 11, 2014
Published online: January 7, 2015
Core Tip
Core tip: A deficiency in levels of immunoglobulin E (IgEd) has been associated with chronic inflammatory diseases, immune dysregulation, oncologic diseases, and chronic infections. This retrospective case-control study evaluated the clinical characteristics of Helicobacter pylori (H. pylori)-related dyspeptic syndrome in patients with IgEd. Analyses revealed a higher prevalence of H. pylori infection in dyspeptic patients with IgEd. Furthermore, gastritis and peptic ulcer disease were more prevalent in subjects with IgEd compared with gender- and age-matched H. pylori-infected dyspeptic patients with normal or high serum IgE levels. Finally, patients with IgEd were more likely to present treatment-refractory H. pylori infections.