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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 7, 2015; 21(1): 187-195
Published online Jan 7, 2015. doi: 10.3748/wjg.v21.i1.187
Published online Jan 7, 2015. doi: 10.3748/wjg.v21.i1.187
Enterocyte dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin expression in inflammatory bowel disease
Jing-Qing Zeng, Chun-Di Xu, Tong Zhou, Jing Wu, Kai Lin, Wei Liu, Xin-Qiong Wang, Department of Pediatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Jing-Qing Zeng, Department of Pediatrics, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
Author contributions: Xu CD and Zhou T designed the research; Zeng JQ, Lin K, Liu W and Wang XQ performed the research and analyzed the data; Zeng JQ and Wu J wrote the paper; all the authors have read and approved the final version to be published.
Supported by Grants from the National Natural Science Foundation of China No. 81000163, No. 81070567, and No. 81170363
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Chun-Di Xu, MD, Professor, Department of Pediatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Erlu, Shanghai 200025, China. chundixu55@163.com
Telephone: +86-21-64370045 Fax: +86-21-64333548
Received: May 23, 2014
Peer-review started: May 26, 2014
First decision: June 18, 2014
Revised: July 10, 2014
Accepted: July 24, 2014
Article in press: July 25, 2014
Published online: January 7, 2015
Peer-review started: May 26, 2014
First decision: June 18, 2014
Revised: July 10, 2014
Accepted: July 24, 2014
Article in press: July 25, 2014
Published online: January 7, 2015
Core Tip
Core tip: Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) functions as an adhesion and antigen-presenting molecule. We found that DC-SIGN was expressed by intestinal epithelial cells, which induced differentiation and proliferation of T cells under the control of DC-SIGN.