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World J Gastroenterol. Feb 21, 2014; 20(7): 1839-1845
Published online Feb 21, 2014. doi: 10.3748/wjg.v20.i7.1839
Published online Feb 21, 2014. doi: 10.3748/wjg.v20.i7.1839
Risk factors for bleeding after endoscopic submucosal dissection of colorectal neoplasms
Sho Suzuki, Akiko Chino, Teruhito Kishihara, Naoyuki Uragami, Yoshiro Tamegai, Takanori Suganuma, Junko Fujisaki, Masahiro Igarashi, Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan
Sho Suzuki, Takao Itoi, Takuji Gotoda, Fuminori Moriyasu, Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo 160-0023, Japan
Masaaki Matsuura, Bioinformatics Group, Genome Center, and Division of Cancer Genomics, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan
Author contributions: Suzuki S and Chino A wrote the manuscript and performed most of the research; Chino A, Kishihara T, Uragami N, Tamegai Y, Suganuma T, Fujisaki J and Igarashi M performed the endoscopic procedure and supported the research; Itoi T, Gotoda T and Moriyasu F drafted and revised the manuscript; Matsuura M designed the study and was involved in statistical analysis.
Correspondence to: Sho Suzuki, MD, Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo 135-8550, Japan. sho.suzuki@jfcr.or.jp
Telephone: +81-3-35200111 Fax: +81-3-35200141
Received: August 21, 2013
Revised: November 14, 2013
Accepted: January 2, 2014
Published online: February 21, 2014
Revised: November 14, 2013
Accepted: January 2, 2014
Published online: February 21, 2014
Core Tip
Core tip: Endoscopic submucosal dissection (ESD) has recently been accepted as an effective treatment for colorectal neoplasms, but the risk factors for bleeding following ESD have not been elucidated. We analyzed the relationship between delayed post-ESD bleeding and various factors related to ESD for colorectal neoplasms. The rate of delayed post-ESD bleeding was 4.3%, and univariate and multivariate analyses showed that the location of lesions in the cecum and the presence of significant bleeding during ESD were significantly associated with delayed post-ESD bleeding. Therefore, patients with these risk factors should be carefully managed with additional interventions if necessary.