Published online Feb 21, 2014. doi: 10.3748/wjg.v20.i7.1701
Revised: November 18, 2013
Accepted: December 5, 2013
Published online: February 21, 2014
Core tip: Epidemiological studies suggested a possible higher risk of gastric cancer in patients with diabetes. This article summarizes the findings in four meta-analyses and proposes some mechanisms explaining the association. Findings in the meta-analyses suggested that the association between diabetes and gastric cancer is more remarkable in females and in the Asian populations. Although the mechanisms for such a link remain to be explored, these may involve shared risk factors between diabetes and gastric cancer (such as obesity, insulin resistance, hyperinsulinemia and smoking), hyperglycemia, Helicobacter pylori infection, high salt intake, medications and comorbidities.