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World J Gastroenterol. Feb 7, 2014; 20(5): 1259-1267
Published online Feb 7, 2014. doi: 10.3748/wjg.v20.i5.1259
Published online Feb 7, 2014. doi: 10.3748/wjg.v20.i5.1259
Campylobacter concisus and inflammatory bowel disease
Li Zhang, Hoyul Lee, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia
Michael C Grimm, St George and Sutherland Clinical School, University of New South Wales, Sydney, NSW 2052, Australia
Stephen M Riordan, Gastrointestinal and Liver Unit, The Prince of Wales Hospital, Prince of Wales Clinical School, University of New South Wales, Sydney, NSW 2052, Australia
Andrew S Day, Daniel A Lemberg, Department of Gastroenterology, Sydney Children’s Hospital, Sydney, NSW 2031, Australia
Andrew S Day, Department of Pediatrics, University of Otago, Christchurch, North Dunedin 9016, New Zealand
Andrew S Day, Daniel A Lemberg, School of Women’s and Children’s Health, University of New South Wales, Sydney, NSW 2031, Australia
Author contributions: Zhang L wrote the review and identified the motifs; Lee H analyzed genes and proteins in putative prophages; Grimm MC, Riordan SM, Day AS and Lemberg DA provided critical feedback and helped in editing the manuscript.
Correspondence to: Li Zhang, MBBS, PhD, Senior Lecturer (Medical Microbiology and Immunology), School of Biotechnology and Biomolecular Sciences, University of New South Wales, High St, Kensington, Sydney, NSW 2052, Australia. l.zhang@unsw.edu.au
Telephone: +61-1-93852042 Fax: +61-2-93851483
Received: September 27, 2013
Revised: November 7, 2013
Accepted: December 12, 2013
Published online: February 7, 2014
Revised: November 7, 2013
Accepted: December 12, 2013
Published online: February 7, 2014
Core Tip
Core tip:Campylobacter concisus (C. concisus) is an oral bacterium that was previously shown to be associated with inflammatory bowel disease (IBD). Evidence presented in this review shows that some strains of C. concisus acquired zonula occludens toxin (zot) gene from a virus (prophage), suggesting that a primary barrier function defect caused by C. concisus Zot is a mechanism by which zot-positive C. concisus strains may trigger the onset and relapse of IBD.