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World J Gastroenterol. Dec 28, 2014; 20(48): 18432-18438
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18432
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18432
Pancreatic exocrine insufficiency, diabetes mellitus and serum nutritional markers after acute pancreatitis
Miroslav Vujasinovic, Jana Makuc, Tjasa Vidmar, Department of Internal Medicine, Slovenj Gradec General Hospital, Slovenj Gradec 2380, Slovenia
Bojan Tepes, Abakus Medico Diagnostic Centre, Rogaska Slatina 3250, Slovenia
Sasa Rudolf, Department of Radiology, University Medical Centre Maribor, Maribor 2000, Slovenia
Jelka Zaletel, Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre Ljubljana, Ljubljana 1000, Slovenia
Maja Seruga, Department of Internal Medicine, Murska Sobota General Hospital, Murska Sobota 9001, Slovenia
Bostjan Birsa, Department of Internal Medicine, Celje General Hospital, Celje 3000, Slovenia
Author contributions: Vujasinovic M and Tepes B designed the study and drafted the manuscript; Vujasinovic M, Vidmar T, Seruga M and Birsa B recruited the patients; Rudolf S performed magnetic resonance imaging; Vujasinovic M, Tepes B, Makuc J, and Zaletel J wrote the manuscript.
Correspondence to: Miroslav Vujasinovic, MD, MSc, Department of Internal Medicine, Slovenj Gradec General Hospital, Gosposvetska 1, Slovenj Gradec 2380, Slovenia. mvujas@gmail.com
Telephone: +386-2-8823448 Fax: +386-2-8823505
Received: April 25, 2014
Revised: June 22, 2014
Accepted: August 13, 2014
Published online: December 28, 2014
Revised: June 22, 2014
Accepted: August 13, 2014
Published online: December 28, 2014
Core Tip
Core tip: Endocrine and exocrine pancreatic insufficiency can develop after acute pancreatitis regardless of the severity, etiology, age, gender and number of attacks. In all patients with pancreatic exocrine insufficiency (PEI), at least one serum nutritional marker was below the lower limit of normal regardless of the presence of classical clinical symptoms of PEI. Routine follow-up of patients with acute pancreatitis at least 24 mo after discharge from the hospital is necessary with special emphasis on diabetes detection. Measurement of serum nutritional markers regardless of the presence of other clinical symptoms of PEI can be of clinical importance.