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World J Gastroenterol. Dec 28, 2014; 20(48): 18306-18315
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18306
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18306
Twist1 correlates with poor differentiation and progression in gastric adenocarcinoma via elevation of FGFR2 expression
Dong-Yuan Zhu, Qi-Sen Guo, Yan-Liang Li, Department of Medical Oncology, Shandong Cancer Hospital and Institute, Jinan 250117, Shandong Province, China
Bin Cui, Department of Medical Oncology, Zhangqiu City People’s Hospital, Jinan 250200, Shandong Province, China
Jun Guo, Department of Medical Oncology, Gaomi City TCM Hospital, Weifang 261500, Shandong Province, China
Ji-Xiao Liu, Department of Medical Oncology, Wenshang County People’s Hospital, Jining 272500, Shandong Province, China
Peng Li, Department of Medical Oncology, Yantai Yuhuangding Hospital affiliated to Qingdao University, Yantai 264000, Shandong Province, China
Author contributions: Zhu DY and Li P designed research; Zhu DY performed immunohistochemistry; Zhu DY, Guo QS, Li YL, Cui B, Guo J and Liu JX performed the in vitro experiments; Zhu DY and Li P analyzed data and wrote the paper.
Supported by Medicine and Sanitation Development Project of Shandong Province, No. 2014WS0323
Correspondence to: Peng Li, MD, Department of Medical Oncology, Yantai Yuhuangding Hospital affiliated to Qingdao University, 20 Yudong Road, Yantai 264000, Shandong Province, China. lipengyuhuangding@163.com
Telephone: +86-531-87984079 Fax: +86-531-87984079
Received: June 7, 2014
Revised: July 12, 2014
Accepted: August 13, 2014
Published online: December 28, 2014
Revised: July 12, 2014
Accepted: August 13, 2014
Published online: December 28, 2014
Core Tip
Core tip: The underlying mechanism of Twist1 and fibroblast growth factor receptor (FGFR)2 function in gastric cancer has not been fully elucidated. We assessed expression of Twist1 and FGFR2 in gastric adenocarcinoma tissues by immunohistochemistry and polymerase chain reaction, and demonstrated that Twist1 and FGFR2 expression was significantly associated with differentiation of gastric adenocarcinoma tissue. We found that Twist1 can function as a transcription factor to promote FGFR2 expression. Moreover, Twist1 can induce proliferation, invasion and epithelial-mesenchymal transition (EMT) of gastric cells, in which FGFR2 is required in the Twist1-induced cell invasion and EMT.