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World J Gastroenterol. Dec 28, 2014; 20(48): 18260-18270
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18260
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18260
PBX3 promotes migration and invasion of colorectal cancer cells via activation of MAPK/ERK signaling pathway
Hai-Bo Han, Yuan Zhang, Wei Zhao, Li-Min Wang, Zhi-Qian Zhang, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Cell Biology, Peking University Cancer Hospital and Institute, Beijing 100142, China
Jin Gu, Deng-Bo Ji, Zhao-Wei Li, Department of Colorectal Cancer Surgery, Peking University Cancer Hospital and Institute, Beijing 100142, China
Author contributions: Han HB performed the majority of experiments and wrote the manuscript; Gu J, Ji DB and Li ZW collected the data on colorectal cancer cases and follow-up; Zhang Y, Zhao W and Wang LM provided technical support for this work; and Zhang ZQ designed the study and revised the manuscript.
Supported by Beijing Natural Science Foundation, No. 5122012; National Natural Science Foundation of China, No. 81201964 and No. 81330051
Correspondence to: Zhi-Qian Zhang, PhD, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Cell Biology, Peking University Cancer Hospital and Institute, 52 Fucheng Road, Beijing 100142, China. zlzqzhang@bjmu.edu.cn
Telephone: +86-10-88196792 Fax: +86-10-88122437
Received: March 25, 2014
Revised: May 12, 2014
Accepted: May 19, 2014
Published online: December 28, 2014
Revised: May 12, 2014
Accepted: May 19, 2014
Published online: December 28, 2014
Core Tip
Core tip: Pre-B-cell leukemia homeobox (PBX)3 is a poor prognostic factor for colorectal cancer by promoting cell migration and invasion. We investigated the role of PBX3 in migration and invasion of colorectal cancer cells, and found that PBX3 could induce the invasion and metastasis of colorectal cancer cells partially through activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase signaling pathway.