Original Article
Copyright ©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 28, 2014; 20(48): 18249-18259
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18249
Delayed ethanol elimination and enhanced susceptibility to ethanol-induced hepatosteatosis after liver resection
Xu Liu, Ayako Hakucho, Jinyao Liu, Tatsuya Fujimiya
Xu Liu, Ayako Hakucho, Jinyao Liu, Tatsuya Fujimiya, Department of Legal Medicine, Yamaguchi University Graduate School of Medicine, Yamaguchi 755-8505, Japan
Author contributions: Liu X and Liu J designed the research; Liu X, Hakucho A and Liu J performed the research; Liu X, Liu J, Hakucho A and Fujimiya T analyzed and interpreted the data; Liu X and Liu J wrote the paper.
Supported by Japan Society for the Promotion of Science’s Grants-in-Aid for Scientific Research, No. 22590635
Correspondence to: Jinyao Liu, MD, PhD, Department of Legal Medicine, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan. czhliu@yamaguchi-u.ac.jp
Telephone: +81-836-222234 Fax: +81-836-222232
Received: June 4, 2014
Revised: July 4, 2014
Accepted: July 29, 2014
Published online: December 28, 2014
Core Tip

Core tip: Pair-feeding was performed with control or ethanol liquid diet for 28 d in sham-operated (Sham) and partial hepatectomy (PH) rats. In PH rats, ethanol induced hepatic steatosis with liver dysfunction and higher residual blood ethanol concentrations without up-regulation of hepatic class-1 alcohol dehydrogenase (Adh1) gene expression, which was present in the Sham-ethanol rats. One week after PH, liver weight, function, and lipid metabolism-related gene expressions recovered; but Adh1 gene expression did not. Desensitization to post-hepatectomy ethanol treatment and the slow recovery of Adh1 expression from PH enhanced the susceptibility to ethanol-induced hepatic steatosis in the rats post PH.