Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18151
Revised: August 18, 2014
Accepted: September 29, 2014
Published online: December 28, 2014
Core tip: Over the last years the treatment of colorectal cancer has become increasingly dependent on individual patient profiling with regard to both microbiology and genetics. Apart from lifestyle factors and age, genetic predisposition, inflammation and impact of the microbiome appear to be important contributors to malignant transformation in the colon. The review gives an update on colorectal carcinogenesis.