El-Karaksy HM, Mohsen LM, Saleh DA, Hamdy MS, Yassin NA, Farouk M, Salit ME, El-Shabrawi MH. Applicability and efficacy of a model for prevention of perinatal transmission of hepatitis B virus infection: Single center study in Egypt. World J Gastroenterol 2014; 20(45): 17075-17083 [PMID: 25493019 DOI: 10.3748/wjg.v20.i45.17075]
Corresponding Author of This Article
Hanaa M El-Karaksy, Professor, Department of Pediatrics, Kasr Al-Ainy School of Medicine, Cairo University, 44 Mohei El-Deen Abu El-Ezz Street, Dokki, Cairo 11562, Egypt. hanaakaraksy@kasralainy.edu.eg
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Research Report
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World J Gastroenterol. Dec 7, 2014; 20(45): 17075-17083 Published online Dec 7, 2014. doi: 10.3748/wjg.v20.i45.17075
Applicability and efficacy of a model for prevention of perinatal transmission of hepatitis B virus infection: Single center study in Egypt
Hanaa M El-Karaksy, Lamiaa M Mohsen, Doa’a A Saleh, Mona S Hamdy, Noha A Yassin, Mohamed Farouk, Mohamed E Salit, Mortada H El-Shabrawi
Hanaa M El-Karaksy, Lamiaa M Mohsen, Noha A Yassin, Mohamed Farouk, Mortada H El-Shabrawi, Department of Pediatrics, Kasr Al-Ainy School of Medicine, Cairo University, Cairo 11562, Egypt
Doa’a A Saleh, Department of Community Medicine, Kasr Al-Ainy School of Medicine, Cairo University, Cairo 11566, Egypt
Mona S Hamdy, Department of Clinical and Chemical Pathology, Kasr Al-Ainy School of Medicine, Cairo University, Cairo 11566, Egypt
Mohamed E Salit, Department of Obstetrics and Gynecology, Kasr Al-Ainy School of Medicine, Cairo University, Cairo 11566, Egypt
Author contributions: El-Karaksy HM, Mohsen LM, Saleh DA and El-Shabrawi MH were involved in the study concept and design; Yassin NA, Farouk M and Salit ME were involved in patient recruitment and screening of mothers; El-Karaksy HM and Yassin NA were involved in immunoprophylaxis and follow up of infants; Saleh DA did the statistical analysis; Hamdy MS did the laboratory work; El-Karaksy HM, Mohsen LM and Saleh DA shared in data interpretation and writing of results; El-Karaksy HM, Mohsen LM and Saleh DA wrote the manuscript; all authors reviewed, revised and approved the manuscript.
Supported by Partially by Cairo University
Correspondence to: Hanaa M El-Karaksy, Professor, Department of Pediatrics, Kasr Al-Ainy School of Medicine, Cairo University, 44 Mohei El-Deen Abu El-Ezz Street, Dokki, Cairo 11562, Egypt. hanaakaraksy@kasralainy.edu.eg
Telephone: +20-2-33375913 Fax: +20-2-25311616
Received: February 26, 2014 Revised: April 29, 2014 Accepted: July 24, 2014 Published online: December 7, 2014
Core Tip
Core tip: Perinatal transmission of hepatitis B virus (HBV) is still a threat in Egypt despite a successful immunization program for infants. In this work we tried to assess the risk factors for maternal acquisition of HBV and study a model for prevention of perinatal transmission of HBV. To achieve our aim we screened 2000 pregnant women for hepatitis B virus surface antigen. Risk factors for HBV acquisition were mostly related to medical care. We encountered a high dropout rate of women who could not be reached to offer their newborns immunoprophylaxis. For those who received immunoprophylaxis after birth, a success rate of 92.6% was achieved. An awareness campaign has to precede implementation of a national program for prevention of perinatal transmission of HBV.
