Published online Dec 7, 2014. doi: 10.3748/wjg.v20.i45.16841
Revised: July 16, 2014
Accepted: September 5, 2014
Published online: December 7, 2014
Core tip: At the moment, there is no standardized treatment for non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH); the first-line approach remains lifestyle changes (diet and physical exercise). The high risk of complications associated with NAFLD/NASH, such as cardiovascular diseases and the incidence of hepatocellular carcinoma, make it necessary to apply appropriate medications to stop the progression of the disease. Considering the pathogenetic pathways known today, several therapeutic targets have been proposed, including some that look very promising; still, innovative pharmacological strategies are absolutely needed. Below, we report the real efficacies of fatty liver therapies and the most recent studies investigating this field.