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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 21, 2014; 20(43): 16334-16342
Published online Nov 21, 2014. doi: 10.3748/wjg.v20.i43.16334
Published online Nov 21, 2014. doi: 10.3748/wjg.v20.i43.16334
Diagnostic value of interleukin-8 in colorectal cancer: A case-control study and meta-analysis
Wen-Jun Jin, Wen-Li Xu, Department of Clinical Laboratory, Huzhou Central Hospital, Huzhou 313000, Zhejiang Province, China
Jin-Ming Xu, Pei-Wei Li, Department of Epidemiology and Health Statistics, Zhejiang University School of Public Health, Hangzhou 310058, Zhejiang Province, China
Dong-Hua Gu, Department of Pathology, Huzhou Central Hospital, Huzhou 313000, Zhejiang Province, China
Author contributions: Jin WJ and Xu JM contributed equally to this work; Jin WJ and Xu JM designed the research, analyzed the results and wrote the manuscript; Xu JM and Xu WL performed the research and conducted the original study; Gu DH and Li PW analyzed the data and helped design the study; all authors have read and approved the final manuscript.
Correspondence to: Wen-Jun Jin, MD, Department of Clinical Laboratory, Huzhou Central Hospital, No. 198 Hongqi Road, Huzhou 313000, Zhejiang Province, China. huzhoujwj@163.com
Telephone: +86-572-2121323
Received: April 8, 2014
Revised: June 11, 2014
Accepted: June 25, 2014
Published online: November 21, 2014
Revised: June 11, 2014
Accepted: June 25, 2014
Published online: November 21, 2014
Core Tip
Core tip: Serum cytokine concentrations may reflect inflammatory processes during the carcinogenesis of colorectal cancer (CRC). The authors conducted an original study to explore the diagnostic value of interleukin-8 (IL-8) in CRC. Besides, standard statistical methods for meta-analysis were applied in the present study. Six studies were finally included (including our study). The pooled results suggested that serum IL-8 is a promising biomarker for CRC detection and may represent a clinically useful tool to identify high-risk patients.