Yu WD, Peng YF, Pan HD, Wang L, Li K, Gu J. Phosphatidylinositol 3-kinase CB association with preoperative radiotherapy response in rectal adenocarcinoma. World J Gastroenterol 2014; 20(43): 16258-16267 [PMID: 25473181 DOI: 10.3748/wjg.v20.i43.16258]
Corresponding Author of This Article
Jin Gu, MD, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Colorectal Surgery, Peking University Cancer Hospital and Institute, 52 Fucheng Road, Haidian District, Beijing 100142, China. zlgujin@126.com
Research Domain of This Article
Oncology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
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World J Gastroenterol. Nov 21, 2014; 20(43): 16258-16267 Published online Nov 21, 2014. doi: 10.3748/wjg.v20.i43.16258
Phosphatidylinositol 3-kinase CB association with preoperative radiotherapy response in rectal adenocarcinoma
Wei-Dong Yu, Yi-Fan Peng, Hong-Da Pan, Lin Wang, Kun Li, Jin Gu
Wei-Dong Yu, Kun Li, Institute of Clinical Molecular Biology, People’s Hospital, Peking University, Beijing 100044, China
Yi-Fan Peng, Hong-Da Pan, Lin Wang, Jin Gu, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Colorectal Surgery, Peking University Cancer Hospital and Institute, Beijing 100142, China
Kun Li, Department of Gastroenterology, People’s Hospital, Peking University, Beijing 100044, China
Author contributions: Yu WD and Peng YF contributed equally to this work, performed the majority of experiments, provided financial support, and were also involved in designing the study and writing the manuscript; Pan HD and Li K provided vital reagents and analytical tools, and were also involved in revising the manuscript; Wang L collected all the clinical materials; Gu J designed the study and wrote the manuscript.
Supported by Grants from the National Natural Science Foundation of China No. 30872923 and the Peking University People’s Hospital Research and Development Fund No. RDB2007-47, No. RDK2008-01 and No. RDB2011-25
Correspondence to: Jin Gu, MD, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Colorectal Surgery, Peking University Cancer Hospital and Institute, 52 Fucheng Road, Haidian District, Beijing 100142, China. zlgujin@126.com
Telephone: +86-10-88196086 Fax: +86-10-88196086
Received: June 11, 2014 Revised: July 9, 2014 Accepted: August 13, 2014 Published online: November 21, 2014
Core Tip
Core tip: The response of rectal cancer cells to preoperative radiotherapy may be related to the dysregulation of phosphatidylinositol 3-kinase (PI3K) signaling molecules, in particular high expression of PIK3CB. Therefore, we evaluated whether PIK3CB upregulation was involved in poor response to preoperative radiotherapy in patients with rectal adenocarcinoma. We found that high expression of PIK3CB was indeed involved in poor response to preoperative radiotherapy, as well as being associated with adverse outcomes in rectal adenocarcinoma patients treated with 30-Gy/10-fraction preoperative radiotherapy. Using TGX-221 (PIK3CB-specific inhibitor), we showed that inhibition of PIK3CB expression enhanced the response of colorectal cancer cell lines to radiotherapy.
