Published online Nov 21, 2014. doi: 10.3748/wjg.v20.i43.16053
Revised: April 22, 2014
Accepted: July 24, 2014
Published online: November 21, 2014
Core tip: This review discusses the treatment of chronic hepatitis B in patients with underlying severe liver disease, including cirrhosis, acute on chronic liver failure, hepatocellular carcinoma, and those undergoing liver transplantation. Despite the availability of highly potent antiviral drugs, these patients are often difficult to manage. The use of currently available antiviral agents is discussed along with its efficacy in these patients with severe hepatitis B liver disease.