Published online Nov 21, 2014. doi: 10.3748/wjg.v20.i43.15955
Revised: May 9, 2014
Accepted: July 22, 2014
Published online: November 21, 2014
Core tip: Hepatocellular carcinoma (HCC) is currently the sixth most common type of cancer with a high mortality rate and an increasing incidence worldwide. HCC most commonly occurs on ground of a cirrhotic liver but interestingly an increasing proportion of HCCs develop in the non-fibrotic or minimal fibrotic. Although this process is yet to be completely understood, this changing scenario also has impact on the material seen by pathologists, presenting them with new diagnostic dilemmas. This review summarizes recent developments and tries to put new HCC biomarkers in context with the WHOs reclassification.