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World J Gastroenterol. Oct 28, 2014; 20(40): 14950-14957
Published online Oct 28, 2014. doi: 10.3748/wjg.v20.i40.14950
Published online Oct 28, 2014. doi: 10.3748/wjg.v20.i40.14950
Therapeutic effects of globular adiponectin in diabetic rats with nonalcoholic fatty liver disease
Hong Ma, Fan Cui, Xiang-Jiu Yang, Yan-Ling Huang, Department of Endocrinology, Zhongshan Hospital Xiamen University, Xiamen 361004, Fujian Province, China
Hong Ma, Jing-Jing Dong, Guo-Ping You, Department of Endocrinology, Xiamen Zhongshan Teaching Hospital of Fujian Medical University, Xiamen 361004, Fujian Province, China
Hua-Dong Lu, Department of Pathology, Zhongshan Hospital Xiamen University, Xiamen 361004, Fujian Province, China
Author contributions: Ma H designed the study; Ma H and Cui F performed the data analyses and wrote the manuscript; Yang XJ and Huang YL participated in the data collection; Dong JJ, You GP and Lu HD performed the research; all the authors participated in the critical review and final approval of the manuscript.
Supported by Science and Technology Project of Xiamen, China, No. 3502Z20114016
Correspondence to: Hong Ma, MD, PhD, Associate Professor, Department of Endocrinology, Zhongshan Hospital Xiamen University, 209 Hubin South Road, Xiamen 361004, Fujian Province, China. mah-169@163.com
Telephone: +86-592-2590251 Fax: +86-592-2212328
Received: December 15, 2013
Revised: February 14, 2014
Accepted: June 13, 2014
Published online: October 28, 2014
Revised: February 14, 2014
Accepted: June 13, 2014
Published online: October 28, 2014
Core Tip
Core tip: Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and is closely associated with obesity and type 2 diabetes mellitus (T2DM). Adiponectin is a fat-derived hormone with anti-diabetic properties, and evidence indicates that adiponectin plays a protective role in NAFLD. Our study focused on the beneficial roles of adiponectin in T2DM rats with NAFLD as a potential therapeutic target. The findings demonstrated that adiponectin exerts its beneficial effects in T2DM rats with NAFLD by promoting insulin secretion, mediating glucolipid metabolism, regulating insulin receptor expression and alleviating hepatic steatosis.