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World J Gastroenterol. Jan 28, 2014; 20(4): 943-956
Published online Jan 28, 2014. doi: 10.3748/wjg.v20.i4.943
Published online Jan 28, 2014. doi: 10.3748/wjg.v20.i4.943
Genetic and epigenetic biomarkers for diagnosis, prognosis and treatment of colorectal cancer
Fabio Coppedè, Angela Lopomo, Lucia Migliore, Department of Translational Research and New Technologies in Medicine and Surgery, Division of Medical Genetics, University of Pisa, 56126 Pisa, Italy
Fabio Coppedè, Lucia Migliore, Istituto Toscano Tumori (ITT), 50139 Florence, Italy
Roberto Spisni, Department of Surgery, Medical, Molecular, and Critical Area Pathology, University of Pisa, 56126 Pisa, Italy
Author contributions: Coppedè F wrote the introduction and the sections of epigenetic biomarkers and future perspectives; Lopomo A wrote the section of genetic biomarkers; Spisni R and Migliore L critically revised the entire manuscript.
Supported by T Istituto Toscano Tumori (ITT) No. Prot.AOOGRT/325424/Q.80.110 16/12/2009, ‘‘Correlation among epigenetic, environmental and genetic factors in colorectal carcinoma’’
Correspondence to: Lucia Migliore, Professor, Department of Translational Research and New Technologies in Medicine and Surgery, Division of Medical Genetics, University of Pisa, Via S. Giuseppe 22, 56126 Pisa, Italy. lucia.migliore@med.unipi.it
Telephone: +39-50-2211029 Fax: +39-50-2211034
Received: October 2, 2013
Revised: November 21, 2013
Accepted: December 5, 2013
Published online: January 28, 2014
Revised: November 21, 2013
Accepted: December 5, 2013
Published online: January 28, 2014
Core Tip
Core tip: We summarize the most recent findings concerning genetic and epigenetic biomarkers of colorectal cancer. The article aims to provide an overview of the currently available diagnostic and prognostic biomarkers of the disease. Attention is also paid to the possible application of those biomarkers for the choice of the most proper therapy.