Meta-Analysis
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World J Gastroenterol. Oct 14, 2014; 20(38): 14040-14050
Published online Oct 14, 2014. doi: 10.3748/wjg.v20.i38.14040
Accuracy of early detection of colorectal tumours by stool methylation markers: A meta-analysis
Hu Zhang, Jian Qi, Ya-Qiong Wu, Ping Zhang, Jun Jiang, Qi-Xian Wang, You-Qing Zhu
Hu Zhang, Jian Qi, Qi-Xian Wang, You-Qing Zhu, Department of Gastroenterology and Clinical Centre of Intestinal and Colorectal Diseases of Hubei Province, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei Province, China
Ya-Qiong Wu, Department of Dermatology, Yijishan Hospital of Wannan Medical College, Wuhu 241001, Anhui Province, China
Hu Zhang, Ping Zhang, Jun Jiang, Department of Gastroenterology, Hubei Provincial Corps Hospital, Chinese People’s Armed Police Force, Wuhan 430061, Hubei Province, China
Author contributions: Zhu YQ and Qi J designed this study and critically revised the article; Zhang H and Qi J were responsible for data acquisition and extracting the data; Zhang H drafted the manuscript, analysed the data and interpreted the results; Wu YQ, Zhang P, Jiang J and Wang QX were involved in editing the manuscript; all authors read and approved the final manuscript to be published.
Correspondence to: Jian Qi, PhD, Department of Gastroenterology and Clinical Centre of Intestinal and Colorectal Diseases of Hubei Province, Zhongnan Hospital of Wuhan University, No. 169 Donghu Road, Wuchang District, Wuhan 430071, Hubei Province, China. qiqidelizi@aliyun.com
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Received: January 24, 2014
Revised: April 24, 2014
Accepted: June 26, 2014
Published online: October 14, 2014
Core Tip

Core tip: The analysis of stool methylation markers as a non-invasive test is important for the early diagnosis of colorectal tumours. However, no consensus has been reached with regard to the role of stool methylation markers in colorectal tumour diagnosis. We performed a meta-analysis of 37 articles, and the pooled results showed that stool methylation markers could be used as a valuable diagnostic and predictive tool for colorectal tumours, and that SFRP2 methylation serves as a promising marker with great potential in early colorectal cancer diagnosis.