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World J Gastroenterol. Oct 14, 2014; 20(38): 13804-13819
Published online Oct 14, 2014. doi: 10.3748/wjg.v20.i38.13804
Pathogenetic mechanisms in gastric cancer
Jing Shi, Yi-Ping Qu, Peng Hou
Jing Shi, Yi-Ping Qu, Peng Hou, Department of Endocrinology, The First Affiliated Hospital of Xi’an Jiaotong University School of Medicine, Xi’an 710061, Shaanxi Province, China
Author contributions: Shi J and Qu YQ collected and analyzed the literature; Hou P wrote the manuscript.
Supported by National Key Program for Developing Basic Research, No. 2010CB933903; the National Natural Science Foundation of China, No. 81171969, No. 81272933 and No. 81372217; and the Fundamental Research Funds for the Central Universities
Correspondence to: Peng Hou, PhD, Department of Endocrinology, The First Affiliated Hospital of Xi’an Jiaotong University School of Medicine, No. 277 of Yanta West Road, Xi’an 710061, Shaanxi Province, China. phou@mail.xjtu.edu.cn
Telephone: +86-298-5324039 Fax: +86-298-5324039
Received: October 24, 2013
Revised: April 30, 2014
Accepted: May 28, 2014
Published online: October 14, 2014
Core Tip

Core tip: Gastric cancer (GC) is a complex, multistep process involving environmental factors and deregulation of canonical oncogenic pathways. Central to these mechanisms are the genetic and epigenetic alterations in these oncogenic signaling pathways. We discuss the recent remarkable progress in understanding the molecular mechanisms and the opening of unprecedented opportunities for the development of novel therapeutic strategies for GC.