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World J Gastroenterol. Sep 28, 2014; 20(36): 13105-13118
Published online Sep 28, 2014. doi: 10.3748/wjg.v20.i36.13105
Published online Sep 28, 2014. doi: 10.3748/wjg.v20.i36.13105
Xiaotan Sanjie decoction attenuates tumor angiogenesis by manipulating Notch-1-regulated proliferation of gastric cancer stem-like cells
Bing Yan, Ying Zhao, Li-Juan Xiu, Da-Zhi Sun, Xuan Liu, Ye Lu, Jun Shi, Yin-Cheng Zhang, Yong-Jin Li, Xiao-Wei Wang, Yu-Qi Zhou, Shou-Han Feng, Can Lv, Pin-Kang Wei, Zhi-Feng Qin, Department of Traditional Chinese Medicine, Changzheng Hospital, the Second Military Medical University, Shanghai 200003, China
Long Liu, Department of Traditional Chinese Medicine, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China
Author contributions: Yan B and Liu L performed the majority of experiments; Xiu LJ, Sun DZ, Liu X, Lu Y, Shi J, Zhang YC, Li YJ, Wang XW, Zhou YQ, Feng SH and Lv C provided vital reagents and analytical tools and were also involved in editing the manuscript; Bing Y, Wei PK and Qin ZF designed the study and wrote the manuscript; Yan B and Liu L contributed equally to the work.
Supported by Project of Experimental Animal Research (the Science and Technology Commission of Shanghai), No. 13140901803
Correspondence to: Zhi-Feng Qin, MD, Department of Traditional Chinese Medicine, Changzheng Hospital, the Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China. yanbing3741@gmail.com
Telephone: +86-21-81885476 Fax: +86-21-63520020
Received: November 7, 2013
Revised: February 10, 2014
Accepted: May 19, 2014
Published online: September 28, 2014
Revised: February 10, 2014
Accepted: May 19, 2014
Published online: September 28, 2014
Core Tip
Core tip: Cancer stem-like cells (CSCs) are involved in tumor angiogenesis and have a higher capacity for secreting vascular endothelial growth factor (VEGF) than non-CSCs. Notch-1 was important in the control of the proliferation of many CSCs; targeting Notch-1 could result in a reduced CSC pool size and decreased levels of VEGF. Our study indicated that CD44+ GCSCs showed superior proliferation and higher VEGF secretion than non-CSCs; these traits were accompanied by high expression of Notch-1. Xiaotan Sanjie decoction could inhibit the proliferation of GCSCs and down-regulate microvessel density in a dose-dependent manner, which could be at least partially explained by its role in manipulating Notch-1.