Copyright ©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 28, 2014; 20(36): 13079-13087
Published online Sep 28, 2014. doi: 10.3748/wjg.v20.i36.13079
Role of Nrf2 in chronic liver disease
Wei Tang, Yong-Fang Jiang, Murugavel Ponnusamy, Mamadou Diallo
Wei Tang, Yong-Fang Jiang, Liver Diseases Research Center, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
Murugavel Ponnusamy, Department of Medicine, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI 02903, United States
Mamadou Diallo, Department of Immunology and Infectious Diseases, Harvard School of Public Health, Harvard University, Boston, MA 02115-6018, United States
Author contributions: Tang W, Diallo M and Ponnusamy M drafted the manuscript; Jiang YF designed and revised the article.
Supported by The Scientific Research Projects from the Development and Reform Commission of Hunan Province, China, No. 2011 (1318), No. 2012 (1493) and No. 2013 (1132)
Correspondence to: Yong-Fang Jiang, MD, PhD, Liver Diseases Research Center, The Second Xiangya Hospital, Central South University, No.139 Middle Renmin Road, Changsha 410011, Hunan Province, China.
Telephone: +86-731-85292105 Fax: +86-731-85292173
Received: March 11, 2014
Revised: May 8, 2014
Accepted: May 25, 2014
Published online: September 28, 2014
Core Tip

Core tip: Chronic liver disease is associated with an imbalance, comprising increased reactive oxygen species and decreased net antioxidant activity. Oxidative stress plays an important role in the pathophysiological changes of liver diseases. Nuclear erythroid 2-related factor 2 (Nrf2) can activate cytoprotective genes and has a crucial role against oxidative stress to protect hepatic cells from oxidative damage. This article focuses on the activation the Nrf2-mediated antioxidant response, which prevents the progression of chronic liver disease and presents new treatment opportunities. Accordingly, integrative therapeutic strategies including Nrf2 activators have great potential as therapeutic agents against oxidative stress during chronic liver injuries.