Dongiovanni P, Romeo S, Valenti L. Hepatocellular carcinoma in nonalcoholic fatty liver: Role of environmental and genetic factors. World J Gastroenterol 2014; 20(36): 12945-12955 [PMID: 25278690 DOI: 10.3748/wjg.v20.i36.12945]
Corresponding Author of This Article
Luca Valenti, MD, Assistant Professor, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Pad. Granelli via F Sforza 35, 20122 Milano, Italy. luca.valenti@unimi.it
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Topic Highlight
Open-Access Policy of This Article
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World J Gastroenterol. Sep 28, 2014; 20(36): 12945-12955 Published online Sep 28, 2014. doi: 10.3748/wjg.v20.i36.12945
Hepatocellular carcinoma in nonalcoholic fatty liver: Role of environmental and genetic factors
Paola Dongiovanni, Stefano Romeo, Luca Valenti
Paola Dongiovanni, Luca Valenti, Internal Medicine 1B, Fondazione IRCCS Ca’ Granda Ospedale Policlinico, 20122 Milano, Italy
Paola Dongiovanni, Luca Valenti, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, 20122 Milano, Italy
Stefano Romeo, Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, 40530 Gothenburg, Sweden
Stefano Romeo, Clinical Nutrition Unit, Department of Medical and Surgical Sciences, University Magna Graecia, 88100 Catanzaro, Italy
Author contributions: Dongiovanni P, Romeo S, Valenti L contributed to literature review and drafting manuscript and revision.
Correspondence to: Luca Valenti, MD, Assistant Professor, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Pad. Granelli via F Sforza 35, 20122 Milano, Italy. luca.valenti@unimi.it
Telephone: +39-25-0320278 Fax: +39-25-0320296
Received: February 17, 2014 Revised: April 28, 2014 Accepted: May 25, 2014 Published online: September 28, 2014
Core Tip
Core tip: Nonalcoholic fatty liver disease (NAFLD) associated with obesity, insulin resistance, and type 2 diabetes, is an increasingly recognized trigger of hepatocellular carcinoma (HCC), even in non-cirrhotic livers. The role of inherited factors seems magnified in fatty liver. The common I148M variant of the PNPLA3 gene influencing hepatic lipid metabolism has been associated with HCC. Rare loss-of-function mutations in apolipoprotein B resulting in very low density lipoproteins hepatic retention and in telomerase reverse transcriptase influencing senescence have been linked to HCC in NAFLD. Hepatic stellate cells senescence has also been suggested to bridge tissue aging with microbiota alterations in the pathogenesis of obesity-related HCC.
