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World J Gastroenterol. Sep 28, 2014; 20(36): 12753-12766
Published online Sep 28, 2014. doi: 10.3748/wjg.v20.i36.12753
Immune evasion strategies used by Helicobacter pylori
Taslima T Lina, Shatha Alzahrani, Jazmin Gonzalez, Irina V Pinchuk, Ellen J Beswick, Victor E Reyes
Taslima T Lina, Shatha Alzahrani, Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, United States
Jazmin Gonzalez, MS-III School of Medicine, University of Texas Medical Branch, Galveston, TX 77555, United States
Irina V Pinchuk, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, United States
Ellen J Beswick, Departments of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, United States
Victor E Reyes, Departments of Pediatrics and Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, United States
Author contributions: All authors contributed to the writing of the different sections of this review; Lina TT took the leading role in organizing the topic and Reyes VE was responsible for the outline and editing.
Supported by National Institutes of Health grants K22AI68712, R56DK090090-01; American Gastroenterological Association Research Scholar Award, NIH 1U54RR02614, The University of Texas Medical Branch Clinical and Translational Sciences Award; The American cancer society RSG-10-159-01-LIB, NIH 8UL1TR000041, The University of New Mexico clinical and Translational Science Center; Taslima T Lina is funded by Sealy Centre for Vaccine Development Pre-doctoral fellowship and McLaughlin Pre-doctoral Fellowship, UTMB
Correspondence to: Victor E Reyes, PhD, Departments of Pediatrics and Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555, United States. vreyes@utmb.edu
Telephone: +1-409-7723824 Fax: +1-409-7721761
Received: February 23, 2014
Revised: April 7, 2014
Accepted: May 19, 2014
Published online: September 28, 2014
Core Tip

Core tip:Helicobacter pylori (H. pylori) is an important human pathogen that causes chronic infection in almost half of the population in the world. In the course of 30000 years of co-existence with humans, H. pylori has evolved extensive adaptations that allow it to successfully cause persistent infection in its host in the face of a vigorous innate and adaptive immune response. In this review, we discuss innate and adaptive immune responses to H. pylori and the mechanisms by which H. pylori evades immune-mediated clearance.