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World J Gastroenterol. Sep 21, 2014; 20(35): 12526-12532
Published online Sep 21, 2014. doi: 10.3748/wjg.v20.i35.12526
Necroptosis: An emerging type of cell death in liver diseases
Waqar Khalid Saeed, Dae Won Jun
Waqar Khalid Saeed, Dae Won Jun, Department of Gastroenterology, Hanyang University School of Medicine, Seoul 133-070, South Korea
Author contributions: Jun DW was the guarantor of the article; Saeed WK performed the research and wrote the manuscript; Jun DW contributed to the design of the study.
Supported by A grant of the Korea Healthcare technology R and D Project, Ministry of Health and Welfare, South Korea, NO. A121185
Correspondence to: Dae Won Jun, MD, Department of Gastroenterology, Hanyang University School of Medicine, Hangdang dong 17, Sungdong gu, Seoul 133-070, South Korea. noshin@hanyang.ac.kr
Telephone: +82-2-22908334 Fax: +82-2-22989183
Received: December 28, 2013
Revised: June 3, 2014
Accepted: July 15, 2014
Published online: September 21, 2014
Core Tip

Core tip: Necroptosis has been identified as apoptotic “back up” cell death mechanism. The evidence of necroptosis and protective effects achieved by blocking necroptosis have been extensively reported in recent past such as in renal ischemic/reperfusion injury, myocardial infarction, and acute pancreatitis. However, only a limited number of studies reported necroptosis evidence and significance of key necroptosis molecules, RIP1 and RIP3, in liver related disease conditions. The current review focuses on evidence of necroptosis in liver related disease conditions as well as potential significance of other programmed necrosis pathways.