Published online Sep 7, 2014. doi: 10.3748/wjg.v20.i33.11496
Revised: March 29, 2014
Accepted: May 23, 2014
Published online: September 7, 2014
Core tip: The present work outlines the main data regarding a possible involvement of estrogen receptors in colorectal carcinogenesis, paying particular attention to cancer arising in the course of ulcerative colitis. A protective role for beta receptors has been suggested by many studies. The challenge for the future could be to devise chemopreventive strategies against colorectal carcinoma employing estrogen receptor beta agonists, such as phytoestrogens.