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World J Gastroenterol. Aug 28, 2014; 20(32): 11429-11438
Published online Aug 28, 2014. doi: 10.3748/wjg.v20.i32.11429
Published online Aug 28, 2014. doi: 10.3748/wjg.v20.i32.11429
Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer susceptibility
Lei-Zhou Xia, Peng-Cheng Jiang, Gui Ma, Xue-Feng Bu, Yong-Jun Zhang, Feng Yu, Hua Li, Department of General Surgery, Affiliated People’s Hospital, Jiangsu University, Zhenjiang 212002, Jiangsu Province, China
Yi Liu, Ke-Sen Xu, Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Jinan 250012, Shandong Province, China
Xiao-Zhou Xu, Department of Surgery, Chang-Hai Hospital, The Second Military Medical University, Shanghai 200000, China
Author contributions: Xia LZ and Li H designed the research; Xia LZ, Liu Y, Xu XZ, Jiang PC, Ma G, Bu XF, Zhang YJ, Yu F and Xu KS performed the data search and meta-analysis; Xia LZ wrote the paper.
Correspondence to: Hua Li, MD, Department of General Surgery, Affiliated People’s Hospital, Jiangsu University, No. 8, Dianli Road, Zhenjiang 212002, Jiangsu Province, China. drlihua212@163.com
Telephone: +86-511-88915151 Fax: +86-511-88915151
Received: October 8, 2013
Revised: March 4, 2014
Accepted: May 12, 2014
Published online: August 28, 2014
Revised: March 4, 2014
Accepted: May 12, 2014
Published online: August 28, 2014
Core Tip
Core tip: Many studies have reported associations of methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms with susceptibility to gastric cancer (GC). There are several relevant published meta-analyses about this subject. Nevertheless, these articles failed to analysis MTHFR polymorphisms and GC risk per se in detail as follows. They failed to investigate the difference between gastric cardia cancer and non-cardia GC, and the distinction between diffuse and intestinal subtypes. Consequently, we performed a meta-analysis to clarify the roles of MTHFR C677T and A1298C polymorphisms in GC susceptibility among the eligible studies.