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World J Gastroenterol. Aug 28, 2014; 20(32): 11422-11428
Published online Aug 28, 2014. doi: 10.3748/wjg.v20.i32.11422
Published online Aug 28, 2014. doi: 10.3748/wjg.v20.i32.11422
Efficacy of tandospirone in patients with irritable bowel syndrome-diarrhea and anxiety
Ling Lan, Hao Zhang, Bai-Ling Jia, Department of Gastroenterology, the People’s Hospital, Zhengzhou University, Zhengzhou 450003, Henan Province, China
Yu-Long Chen, Yan-Jun Chu, Jin Wang, Department of Gastroenterology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, Henan Province, China
Shi-Xiao Tang, Guo-Dong Xia, Department of Gastroenterology, the First Affiliated Hospital, Luzhou Medical College, Luzhou 646000, Henan Province, China
Author contributions: Chen YL and Lan L designed the research study; Lan L and Jia BL performed the research and wrote the paper; Chu YJ and Wang J collected the data and performed statistical analysis; Tang SX and Xia GD collected the data; all authors had approved the final version of the manuscript, including the authorship list.
Correspondence to: Yu-Long Chen, Professor, Department of Gastroenterology, the First Affiliated Hospital, Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou 450052, China. yulongchen@hotmail.com
Telephone: +86-371-65580603 Fax: +86-371-65964376
Received: December 22, 2013
Revised: April 3, 2014
Accepted: May 28, 2014
Published online: August 28, 2014
Revised: April 3, 2014
Accepted: May 28, 2014
Published online: August 28, 2014
Core Tip
Core tip: Irritable bowel syndrome (IBS) is associated with psychological stress, anxiety and depression, which may contribute to perpetuating the condition. IBS-diarrhea (IBS-D), an isotype of IBS, is often accompanied by anxiety, and conventional therapy is unfavorable. IBS-D may respond positively to anti-anxiety/-depression therapies. However, existing medications are not sufficiently effective for patients with IBS-D. To our knowledge, few randomized, controlled and multi-center studies have focused on the efficacy of anti-anxiety agents in IBS-D patients. This is a prospective, randomized, controlled study to evaluate the efficacy of tandospirone in patients with combined IBS-D and anxiety.