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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 28, 2014; 20(32): 11356-11362
Published online Aug 28, 2014. doi: 10.3748/wjg.v20.i32.11356
Published online Aug 28, 2014. doi: 10.3748/wjg.v20.i32.11356
Effect of low-dose tacrolimus with mycophenolate mofetil on renal function following liver transplantation
Jing-Cheng Hao, Wen-Tao Wang, Lu-Nan Yan, Bo Li, Tian-Fu Wen, Jia-Yin Yang, Ming-Qing Xu, Ji-Chun Zhao, Yong-Gang Wei, Department of Liver Surgery, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Yan LN and Wang WT designed the research; Hao JC collected and analyzed the data; Li B, Wen TF, Yang JY, Xu MQ, Zhao JC and Wei YG performed data acquisition and provided technical support; and Hao JC wrote the paper.
Supported by Grants from The National Sciences and Technology Major Project of China, No. 2012ZX10002-016 and 2012ZX10002-017
Correspondence to: Lu-Nan Yan, MD, Department of Liver Surgery, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China. yanlvnan688@163.com
Telephone: +86-28-85422867 Fax: +86-28-85422867
Received: January 12, 2014
Revised: March 15, 2014
Accepted: April 21, 2014
Published online: August 28, 2014
Revised: March 15, 2014
Accepted: April 21, 2014
Published online: August 28, 2014
Core Tip
Core tip: Calcineurin inhibitor nephrotoxicity has been proposed to have a central role in chronic kidney disease, which has become a leading cause of long-term morbidity and mortality after liver transplantation. This study was conducted in 689 consecutive liver transplantation recipients and suggested that the choice of the immunosuppression therapy should be low-dose tacrolimus combined with mycophenolate mofetil, as this treatment was associated with better renal function and a higher patient survival rate.