Published online Aug 28, 2014. doi: 10.3748/wjg.v20.i32.11182
Revised: February 15, 2014
Accepted: April 15, 2014
Published online: August 28, 2014
Core tip: Risk factors for developing pancreatic cancer include multiple genetic syndromes as well as modifiable risk factors. These factors can raise the risk of developing pancreatic cancer up to 132-fold over the general population. Several large-volume centers have initiated screening protocols, and consensus-based guidelines for screening high-risk groups have recently been published. The focus of this review will be both the genetic and modifiable risk factors implicated in pancreatic cancer, as well as a review of screening strategies and their diagnostic yields.