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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 21, 2014; 20(31): 10944-10952
Published online Aug 21, 2014. doi: 10.3748/wjg.v20.i31.10944
Published online Aug 21, 2014. doi: 10.3748/wjg.v20.i31.10944
Model based on γ-glutamyltransferase and alkaline phosphatase for hepatocellular carcinoma prognosis
Xin-Sen Xu, Yong Wan, Si-Dong Song, Wei Chen, Run-Chen Miao, Yan-Yan Zhou, Ling-Qiang Zhang, Kai Qu, Si-Nan Liu, Chang Liu, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Yue-Lang Zhang, Department of Radiology, the First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Ya-Feng Dong, Department of Obstetrics and Gynecology, University of Kansas School of Medicine, Kansas City, KS 66160, United States
Author contributions: Xu XS designed the research and wrote this paper; Wan Y and Song SD performed the statistical analysis; Chen W, Miao RC, Zhou YY and Zhang LQ were involved in collecting patient data; Qu K and Liu SN took part in literature searches; Zhang YL and Dong YF edited the manuscript; Liu C designed the research.
Supported by National natural science foundation of China, No. 81272644 and No. 81201549
Correspondence to: Chang Liu, MD, PhD, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi’an Jiaotong University, No. 277, West Yanta Road, Xi’an 710061, Shaanxi Province, China. liuchangdoctor@163.com
Telephone: +86-29-82654746 Fax: +86-29-82654746
Received: January 24, 2014
Revised: April 1, 2014
Accepted: May 19, 2014
Published online: August 21, 2014
Revised: April 1, 2014
Accepted: May 19, 2014
Published online: August 21, 2014
Core Tip
Core tip: To determine the optimal cut-off value of alkaline phosphatase (ALP) and γ-glutamyltransferase (GGT) to predict hepatocellular carcinoma (HCC) prognosis after liver resection, and to establish a scoring model, we analyzed the outcome of 172 HCC patients who underwent liver resection. Receiver operating characteristic curve analysis was performed to determine the cut-off value of ALP and GGT. Preoperative risk factors for survival were evaluated by multivariate analysis. Based on the significant factors, a prognostic scoring model was established. Our model might affect the outcome of patients in different risk groups, and was superior to the traditional risk markers.