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World J Gastroenterol. Aug 21, 2014; 20(31): 10886-10894
Published online Aug 21, 2014. doi: 10.3748/wjg.v20.i31.10886
Published online Aug 21, 2014. doi: 10.3748/wjg.v20.i31.10886
Oxytocin decreases colonic motility of cold water stressed rats via oxytocin receptors
Xiao Yang, Tao-Fang Xi, Yu-Xian Li, Hai-Hong Wang, Ying Qin, Jie-Ping Zhang, Wen-Ting Cai, Meng-Ting Huang, Ji-Qiao Shen, Xi-Min Fan, Dong-Ping Xie, Department of Physiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200092, China
Xuan-Zheng Shi, Division of Gastroenterology, Department of Internal Medicine, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-1064, United States
Author contributions: Yang X, Xi TF and Xie DP conceived and designed the experiments; Yang X, Xi TF, Cai WT, Huang MT, Shen JQ and Fan XM performed the experiments; Li YX, Wang HH, Qin Y and Zhang JP analyzed the data; Yang X, Xi TF and Xie DP wrote the paper; Shi XZ and Xie DP revised the paper; Yang X and Xi TF contributed equally to this work.
Supported by National Natural Science Foundation of China, No. 30872475 and No. 31271234
Correspondence to: Dong-Ping Xie, MD, PhD, Department of Physiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, 1239 Siping Road, Shanghai 200092, China. xiedping@tongji.edu.cn
Telephone: + 86-21-65985448 Fax: + 86-21-65987071
Received: March 13, 2014
Revised: April 25, 2014
Accepted: July 22, 2014
Published online: August 21, 2014
Revised: April 25, 2014
Accepted: July 22, 2014
Published online: August 21, 2014
Core Tip
Core tip: Colon transit was decreased and oxytocin-induced inhibition of colonic contraction was enhanced in rats with cold water intake. Atosiban and tetrodotoxin inhibited the effect of oxytocin on colonic motility. Cold water intake increased blood concentration of oxytocin and expression of oxytocin receptors in colon. Estradiol regulated blood concentration of oxytocin and oxytocin-induced colonic contraction. The results suggested that cold water intake inhibited colonic motility through oxytocin-oxytocin receptor signaling in the myenteric nervous system pathway, which is estrogen dependent. The estradiol-oxytocin-oxytocin receptor-colonic contractile pathway might be a new therapeutic target for irritable bowel syndrome in females.