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World J Gastroenterol. Aug 21, 2014; 20(31): 10876-10885
Published online Aug 21, 2014. doi: 10.3748/wjg.v20.i31.10876
Published online Aug 21, 2014. doi: 10.3748/wjg.v20.i31.10876
Beneficial effect of butyrate, Lactobacillus casei and L-carnitine combination in preference to each in experimental colitis
Mahsa Moeinian, Seyedeh Farnaz Ghasemi-Niri, Shilan Mozaffari, Maryam Baeeri, Mona Navaea-Nigjeh, Mohammad Abdollahi, Department of Toxicology and Pharmacology, Toxicology and Poisoning Research Center, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 1417614411, Iran
Amir Hossein Abdolghaffari, International Campus, Tehran University of Medical Sciences, Tehran 1417614411, Iran
Amir Hossein Abdolghaffari, Pharmacology and Applied Medicine Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj 31375369, Iran
Author contributions: Moeinian M searched the literature, read the papers, gathered the data, drafted the manuscript and monitored the in vivo and in vitro testings; Ghasemi-Niri SF assisted in lab works, gavaged the animals, and fulfilled statistical analyses of macroscopic and microscopic data; Mozaffari S helped in design of the study and edited the manuscript; Abdolghaffari AH gavaged the animals, obtained colonic samples, prepared and described pathological images; Baeeri M analysed the biomarkers; Navaea-Nigjeh M assisted in analysing the biomarkers; Abdollahi M gave the idea, designed the study, supervised the whole work, and edited the manuscript.
Supported by Tehran University of Medical Sciences (partially)
Correspondence to: Mohammad Abdollahi, Professor, Department of Toxicology and Pharmacology, Toxicology and Poisoning Research Center, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 1417614411, Iran. mohammad@tums.ac.ir
Telephone: +98-21-64122319 Fax: +98-21-66959104
Received: November 2, 2013
Revised: February 11, 2014
Accepted: April 5, 2014
Published online: August 21, 2014
Revised: February 11, 2014
Accepted: April 5, 2014
Published online: August 21, 2014
Core Tip
Core tip: Inflammatory bowel disease (IBD) is among the common diseases in the world that have no absolute cure yet. Although corticosteroids, immunosuppressants, and aminosalicylates are conventionally used in management of IBD, their side effects reduce patients’ compliance. In this paper, we have shown that the combination of butyrate, Lactobacillus casei, and, L-carnitine reduces the amount of oxidative stress within the colon and provides significant anti-inflammatory effects. Optimistically, the proposed combination is from components with no serious side effects and is more economical to manufacture.