Published online Aug 21, 2014. doi: 10.3748/wjg.v20.i31.10825
Revised: February 13, 2014
Accepted: April 5, 2014
Published online: August 21, 2014
Core tip: Some of the targets discussed here have been discovered to enhance the effectiveness of gemcitabine upon co-administration of the corresponding agents, for instance, hyaluronidase can deplete hyaluronan in stromal region to enhance gemcitabine delivery. Besides, some signaling molecules, e.g., RalGEF-RAl, Rac1, and PAR2 are being targeted to suppress metastasis. Tumour proliferation is limited upon DR5 activated apoptosis and others promising therapeutic areas like epigenetic modifiers; IAP, miR, lncRNA, and cancer stem cells-tumour microenvironment will also be discussed.