Published online Jan 21, 2014. doi: 10.3748/wjg.v20.i3.724
Revised: November 9, 2013
Accepted: December 5, 2013
Published online: January 21, 2014
Core tip: Treatment regimens for Helicobacter are cumbersome, prone to side effects and often have low success rates. Fermented milk and related proteins have often been explored as potential candidates for complementary therapy. The current review sought to summarize the current evidence available on their role in Helicobacter pylori eradication and found substantial evidence to support the use of fermented milk based probiotic preparation and bovine lactoferrin. Evidence for other whey proteins is preliminary and requires substantiation. Further work is necessary to identify the optimal substrate, fermentation process, dose and the ideal clinical setting. The potential of this group in antibiotic resistance or treatment failure settings also presents interesting possibilities.