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World J Gastroenterol. Jan 21, 2014; 20(3): 706-713
Published online Jan 21, 2014. doi: 10.3748/wjg.v20.i3.706
Published online Jan 21, 2014. doi: 10.3748/wjg.v20.i3.706
Helicobacter pylori-negative, non-steroidal anti-inflammatory drug: Negative idiopathic ulcers in Asia
Katsunori Iijima, Takeshi Kanno, Tomoyuki Koike, Tooru Shimosegawa, Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Miyagi, Japan
Author contributions: Iijima K substantial contributions to conception and design, interpretation of data, drafting the article, final approval of the version to be published; Kanno T, Koike T and Shimosegawa T acquisition of data, revising it critically for important intellectual content, final approval of the version to be published.
Correspondence to: Iijima Katsunori, MD, Division of Gastroenterology, Tohoku University Graduate School of Medicine, Seiryo-machi, Aobaku, Sendai 980-8574, Miyagi, Japan. kiijima@med.tohoku.ac.jp
Telephone: +81-22-7177171 Fax: +81-22-7177177
Received: September 11, 2013
Revised: November 7, 2013
Accepted: December 3, 2013
Published online: January 21, 2014
Revised: November 7, 2013
Accepted: December 3, 2013
Published online: January 21, 2014
Core Tip
Core tip: In Asia, numerous studies reported that idiopathic ulcers accounted for a small percentage of all ulcers in the 1990s, but in the 2000s, multiple studies reported that the proportion of idiopathic ulcers had reached 10%-30%, indicating that the incidence of idiopathic ulcers in Asia has also been rising in recent years. As it is expected that Helicobacter pylori infection rates in Asia will decline further in the future, measures to treat idiopathic ulcers will also likely become more important.