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World J Gastroenterol. Jul 28, 2014; 20(28): 9585-9591
Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9585
Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9585
Alterations in enterocyte mitochondrial respiratory function and enzyme activities in gastrointestinal dysfunction following brain injury
Ke-Jun Zhu, Shi-Ming Zhang, Department of Neurosurgery, the First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China
Ke-Jun Zhu, Hong Huang, Hui Chu, Hang Yu, Department of Trauma Surgery, the 100th Hospital of PLA, Suzhou 215007, Jiangsu Province, China
Author contributions: Zhu KJ and Zhang SM designed the research; Huang H, Chu H and Yu H performed the research; Zhu KJ wrote the paper.
Supported by The Scientific Research Foundation of the Chinese PLA Medical Programs, No. ms031
Correspondence to: Shi-Ming Zhang, Professor, Department of Neurosurgery, the First Affiliated Hospital of Soochow University, 188 Shizi Jie, Suzhou 215006, Jiangsu Province, China. mmboyzkj@hotmail.com
Telephone: +86-512-65063560 Fax: +86-10-65063508
Received: February 9, 2014
Revised: March 26, 2014
Accepted: April 21, 2014
Published online: July 28, 2014
Revised: March 26, 2014
Accepted: April 21, 2014
Published online: July 28, 2014
Core Tip
Core tip: Many researchers over the years have attempted to reveal the possible mechanism involved in gastrointestinal dysfunction following traumatic brain injury (TBI). Mitochondria are thought to be the primary target of oxidative damage and play an important role in oxidative stress. However, alterations in rat enterocyte mitochondrial respiratory function and enzyme activities following TBI have not been described previously. The purpose of this study was to determine the effect of TBI on rat enterocyte mitochondrial respiratory function and enzyme activities, as well as to reveal the alterations in rat enterocyte mitochondrial function following TBI.