Research Report
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World J Gastroenterol. Jul 28, 2014; 20(28): 9519-9527
Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9519
Remote ischemic postconditioning protects against gastric mucosal lesions in rats
Tao Wang, Ye-Ting Zhou, Xin-Nian Chen, An-Xiang Zhu, Bo-Hua Wu
Tao Wang, Department of Anesthesiology, Shuyang People’s Hospital, Shuyang 223600, Jiangsu Province, China
Ye-Ting Zhou, Bo-Hua Wu, Department of General Surgery, Shuyang People’s Hospital, Shuyang 223600, Jiangsu Province, China
Xin-Nian Chen, Institute of Pathophysiology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, Gansu Province, China
An-Xiang Zhu, Department of Pharmacy, Shuyang People’s Hospital, Shuyang 223600, Jiangsu Province, China
Author contributions: Wang T and Zhou YT contributed equally to this work, designed the research and wrote the paper; Wang T, Chen XN, Zhu AX and Wu BH provided new reagents/analytic tools, performed the research, analyzed the data and edited the manuscript.
Supported by Lanzhou City Science and Technology Development Plan, No. 2009-1-52
Correspondence to: Xin-Nian Chen, PhD, Institute of Pathophysiology, School of Basic Medical Sciences, Lanzhou University, No. 222 Tianshuinan Road, Lanzhou 730000, Gansu Province, China. chenxn@lzu.edu.cn
Telephone: +86-931-8915023 Fax: +86-931-8915023
Received: October 8, 2013
Revised: January 21, 2014
Accepted: June 12, 2014
Published online: July 28, 2014
Core Tip

Core tip: In the present study, the effects of remote ischemic postconditioning (RIP) on limb ischemia-reperfusion-induced gastric mucosal lesions were evaluated. This study demonstrates that RIP performed immediately before reperfusion ameliorates gastric mucosal lesions, increases superoxide dismutase activity, and decreases xanthine oxidase and myeloperoxidase activities and the level of malondialdehyde in gastric homogenates. In addition, RIP attenuated serum lactate dehydrogenase and creatine kinase activities, and significantly reduced the concentration of tumor necrosis factor-α, while elevating the concentration of interleukin-10.