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World J Gastroenterol. Jul 21, 2014; 20(27): 9178-9184
Published online Jul 21, 2014. doi: 10.3748/wjg.v20.i27.9178
Published online Jul 21, 2014. doi: 10.3748/wjg.v20.i27.9178
Hepatitis B surface antigen levels during natural history of chronic hepatitis B: A Chinese perspective study
Lin-Yan Zeng, Jiang-Shan Lian, Jian-Yang Chen, Hong-Yu Jia, Yi-Min Zhang, Dai-Rong Xiang, Liang Yu, Jian-Hua Hu, Ying-Feng Lu, Lin Zheng, Lan-Juan Li, Yi-Da Yang, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Author contributions: Zeng LY and Lian JS performed the majority of experiments; Chen JY, Jia HY, Zhang YM, Xiang DR, Yu L, Hu JH, Lu YF provided analytical tools and revised the manuscript; Zheng L, Li LJ and Yang YD designed the study; Lian JS and Yang YD wrote the manuscript.
Supported by National Key Program for Infectious Diseases of China to Yang YD, No. 2013ZX10002001; and the 12th Five-Year Significant New Drugs Creation Plan of the Ministry of Science and Technology of China to Li LJ, No. 2011ZX09302-003-03
Correspondence to: Yi-Da Yang, Professor, State Key Laboratory for Diagnosis and Treatment of Infectious Disease, the First Affiliated Hospital of Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. yangyida65@163.com
Telephone: +86-571-87236755 Fax: +86-571-87236755
Received: November 17, 2013
Revised: March 12, 2014
Accepted: April 21, 2014
Published online: July 21, 2014
Revised: March 12, 2014
Accepted: April 21, 2014
Published online: July 21, 2014
Core Tip
Core tip: The quantification of serum hepatitis B surface antigen (HBsAg) has been recently advocated as a favorable marker of disease activity in chronic hepatitis B (CHB). Knowledge of HBsAg in the natural history of chronic hepatitis B is important for the management of the disease, but there is a lack of corresponding data on the base level of HBsAg in the natural history of CHB in China. Hence, the aim of this cross-sectional study was to evaluate the levels of HBsAg in consecutive phases of the natural history of hepatitis B virus-infection without the influence of antiviral treatment before, including the patients’ progression to liver cirrhosis.