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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 21, 2014; 20(27): 9121-9127
Published online Jul 21, 2014. doi: 10.3748/wjg.v20.i27.9121
Published online Jul 21, 2014. doi: 10.3748/wjg.v20.i27.9121
Risk factors and surgical outcomes for spontaneous rupture of BCLC stages A and B hepatocellular carcinoma: A case-control study
Jing Li, Liang Huang, Cai-Feng Liu, Jie Cao, Jian-Jun Yan, Feng Xu, Meng-Chao Wu, Yi-Qun Yan, Department of Hepatic Surgery I, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China
Author contributions: Li J and Huang L performed the study; Liu CF, Cao J, Yan JJ and Xu F collected the clinicopathological data and were involved in editing the manuscript; Li J and Huang L wrote the manuscript; Wu MC and Yan YQ designed the study; Li J and Huang L contributed equally to this work.
Supported by Grants of National Science and Technology Major Project Foundation, No. 2008ZX10002-025; and Scientific Research Fund Projects of Shanghai Health Bureau, No. 2009Y066
Correspondence to: Yi-Qun Yan, Professor, Department of Hepatic Surgery I, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, 800 Yinxiang Road, Shanghai 200438, China. ehbhyyq@163.com
Telephone: +86-21-81875501 Fax: +86-21-65562400
Received: January 5, 2014
Revised: March 12, 2014
Accepted: April 15, 2014
Published online: July 21, 2014
Revised: March 12, 2014
Accepted: April 15, 2014
Published online: July 21, 2014
Core Tip
Core tip: There are few reports concerning the risk factors associated with spontaneous rupture of hepatocellular carcinoma (HCC) and the best approach in cases of ruptured HCC. This retrospective case-control study showed that three predictive factors including hypertension, liver cirrhosis and tumor location in segments II, III and VI were associated with spontaneous rupture of HCC. Especially, the relationship between tumor location and spontaneous rupture of HCC was identified for the first time.