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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 14, 2014; 20(26): 8700-8708
Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8700
Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8700
APE1 polymorphisms are associated with colorectal cancer susceptibility in Chinese Hans
Shi-Heng Zhang, Lin-Ang Wang, Zheng Li, Yu Peng, Yan-Ping Cun, Nan Dai, Yi Cheng, He Xiao, Yan-Li Xiong, Dong Wang, Cancer Center, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing 400042, China
Lin-Ang Wang, Chongqing Medical University, Chongqing 400016, China
Author contributions: Zhang SH and Wang LA contributed equally to this work; Zhang SH, Wang LA, Li Z, Peng Y, and Wang D designed the research; Zhang SH, Wang LA, Peng Y, Cheng Y, and Xiong YL performed the research; Zhang SH, Li Z, and Xiao H analyzed the data; Zhang SH and Wang LA wrote the paper; Cun YP, Dai N, and Wang D contributed to editing and revision of the manuscript.
Supported by Grants from the National Natural Science Foundation of China, No. 81171904 and No. 81001000
Correspondence to: Dong Wang, MD, PhD, Cancer Center, Daping Hospital and Research Institution of Surgery, Third Military Medical University, No. 10 Changjiang Zhi Rd, Yuzhong District, Chongqing 400042, China. dongwang64@hotmail.com
Telephone: +86-23-68757151 Fax: +86-23-68894062
Received: November 30, 2013
Revised: March 27, 2014
Accepted: April 21, 2014
Published online: July 14, 2014
Revised: March 27, 2014
Accepted: April 21, 2014
Published online: July 14, 2014
Core Tip
Core tip: There are discrepancies in reports concerning the association between polymorphisms in genes involved in the base excision DNA repair pathway (OGG1, APE1, and XRCC1) and colorectal cancer susceptibility. This study examines four of these polymorphisms in a Chinese Han population from the southwest region of China. Results show that the APE1 148 Glu/Glu genotype is associated with an increased risk of CRC. Moreover, analyses examining gene-behavior interactions revealed that smoking may influence the relationship between the XRCC1 Arg399Gln polymorphism and CRC risk.